Preliminary data presented at the AACR-NCI-EORTC conference will provide insights into the potential of ZW191 in patients with advanced solid tumors, including ovarian cancer, endometrial cancer, and non-small cell lung cancer.Data from the Phase 1 trial of ZW191 provide readthrough to Zymeworks' broader ADC portfolio utilizing its novel bystander active topoisomerase-1 inhibitor payload, ZD06519.VANCOUVER, British Columbia, Oct. 13, 2025 (GLOBE NEWSWIRE) -- Zymeworks Inc. (NASDAQ:ZYME), a clinical-stage biotechnology company developing a diverse pipeline of novel, multifunctional biotherapeutics to improve the standard of care for difficult-to-treat diseases, including cancer, inflammation, and autoimmune disease, today announced the acceptance of a poster presentation discussing preliminary results from a Phase 1 study evaluating ZW191, an antibody-drug conjugate (ADC) targeting folate receptor-⍺ (FR⍺), at the AACR-NCI-EORTC Conference on Molecular Targets and Cancer Therapeutics, being held October 22-26, 2025, in Boston, MA."We are excited to share early clinical data from Part 1 of our first-in-human, Phase 1 trial of ZW191 in patients with advanced solid tumors," said Sabeen Mekan, MD, Senior Vice President of Clinical Development of Zymeworks. "These initial results reinforce our confidence in our novel ADC design and its potential to deliver improved treatments for broader patient populations. ZW191 is the lead product candidate from our broad ADC portfolio utilizing our proprietary payload, ZD06519, and targets FRα, a protein expressed in several difficult-to-treat cancers, underscoring our commitment to developing differentiated therapies for patients who urgently need better treatment options."Presentation DetailsTitle: Preliminary results from a phase 1 first-in-human multicenter open-label study of ZW191, a folate receptor α-targeting antibody-drug conjugate, in patients with advanced solid tumorsSession: Poster Session ADate/Time: Thursday, October 23, 2025 at 12:30-4:00 pm Eastern Time (ET)Investor & Analyst Call A live webcast will be held with lead author Patricia LoRusso, DO, PhD (hc), FAACR and Zymeworks senior management on October 23, 2025 at 3:30 pm ET to discuss the data presented. Dial-in details and webcast replay are available on Zymeworks' website at https://ir.zymeworks.com/events-and-presentations.About ZW191ZW191 is an ADC engineered to target a protein called folate receptor-⍺ found in ~75% of high-grade serous ovarian carcinomas1 and ~70% of lung adenocarcinomas2. ZW191's differentiated design strongly supports its ability to internalize into FR⍺-expressing cells with the potential to release bystander active topoisomerase-1 inhibitor (ZD06519), a novel proprietary ...Full story available on Benzinga.com