Cystic Fibrosis Foundation to provide up to $11 million in additional funding to accelerate development of 4D-710 for cystic fibrosis, following program and clinical data review by its independent scientific advisors Funding supports second 4D-710 dosing ≥1 year post initial Phase 1 dose, advancement into Phase 2, and Phase 3 readinessEnrollment in the Phase 2 stage of the AEROW clinical trial is currently underway, with 2.5E14 vg selected as the anticipated pivotal and commercial doseEMERYVILLE, Calif., Oct. 13, 2025 (GLOBE NEWSWIRE) -- 4D Molecular Therapeutics (NASDAQ:FDMT, 4DMT, or the Company)), a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients, today announced that the Cystic Fibrosis Foundation (CF Foundation) will provide up to $11 million in additional funding, with an initial tranche of $7.5 million, and technical support to accelerate the development of 4D-710 for the treatment of cystic fibrosis (CF) lung disease. This support includes the creation of a new Joint Steering Committee (JSC) with senior clinical development and regulatory expertise to enhance strategic planning, guidance, and coordination of 4D-710's development. With this funding, the CF Foundation has committed nearly $32 million to 4DMT CF programs to date."We are honored to receive the CF Foundation's continued support, which underscores our shared mission to bring transformative new treatments to people with CF," said David Kirn, M.D., Co-founder and Chief Executive Officer of 4DMT. "Our next-generation A101 vector utilized in 4D-710 was invented for efficient aerosol delivery and transduction throughout the lung airways and was designed to enable repeat dosing to maintain clinical benefit over time. This funding and strategic support are critical as we advance 4D-710 through Phase 2, with the goal of delivering a durable, redosable, and variant-agnostic genetic medicine with the potential to become a foundational treatment for individuals with CF with remaining unmet pulmonary needs. We look forward to sharing interim Phase 1 data from the AEROW clinical trial, including functional durability results one to three years post-dosing, and providing a program update by year-end."Funding and Joint Steering Committee to Support Accelerated Late-Stage DevelopmentThe CF Foundation will invest up to $11 million in 4DMT equity in two tranches, with the second tranche subject to specific clinical milestones. The first tranche of $7.5 million closed in October 2025.In addition, the CF Foundation and 4DMT will form a Joint Steering Committee (JSC) with senior clinical development and regulatory expertise to further increase the strategic planning, guidance, and coordination of clinical and operational progress for the development of 4D-710.The funding and JSC will support the following activities:AEROW clinical trial – Phase 1 Redosing Cohort:Selected participants from Phase 1 are expected to receive a second dose (2.5E14 vg), ≥1 year following initial 4D-710 dosingAEROW clinical trial – Phase 2 Cohort:Enrollment has begun with 2.5E14 vg as ...Full story available on Benzinga.com